Diabetic nephropathy: Paricalcitol lowers residual albuminuria in type 2 diabetes
نویسندگان
چکیده
منابع مشابه
Paricalcitol for reduction of albuminuria in diabetes.
Albeit based on robust methods, the study by Dick de Zeeuw and colleagues (Nov 6, p 2010) raises several concerns. First, little attention is given to the fact that the primary endpoint— ie, the eff ect of the vitamin D receptor activator (VDRA) on urinary albuminto-creatinine ratio (UACR)—is actually negative. The positive results on secondary endpoints should thus be used only to generate new...
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PURPOSE Angiotensin-converting-enzyme inhibitors (ACEIs) provide renal protection in patients with type 2 diabetes and microalbuminuria. MATERIAL AND METHODS In the presented study we followed 34 stable, type 2 diabetic patients with persistent albuminuria treated with maximal doses of ACEIs as a part of their anti-hypertensive treatment. Telmisartan--an angiotensin receptor blocker (ARB)--in...
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It is an irony of medical progress that the renal involvement in diabetes mellitus type 2 had been considered twenty years ago (1) as a benign condition for the kidney without causing renal function loss greater than expected from the “normal” aging process. In contrast, today it has become the single most common cause of end-stage renal disease (ESRD) in the entire Western world (2–4). Apart f...
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Diabetic nephropathy (DN) also named diabetic kidney disease (DN) is one of the leading causes of mortality in people with diabetes. The aim of this review is to update the medical literature, the theories behind its early natural history, the pathways of its pathogenesis, its diagnosis and treatment. Poor glycemic control, hyperlipidemia, smoking, oxidative stress, accumulation of advanced gly...
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Diabetic nephropathy is a progressive renal disease with thickening of the glomerular basement membrane and mesangial expansion and proliferation as histological hallmarks. The presence of the glycosaminoglycan side chains of heparan sulfate proteoglycan, an important constituent of the glomerular basement membrane, is decreased in diabetic nephropathy proportionally to the degree of proteinuri...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2011
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2010.183